In addition to blood pressure reduction to calm anxiety in getting to sleep, improved sleep from grapes, one time attributed to melatonin, have shown positive sleep and memory benefits directly from a diet with grape polyphenols.
A higher dietary intake of certain polyphenols found in grapes and other Mediterranean fruits and vegetables have associations with better sleep quality among adult individuals as reported in a 2020 study of 1936 Italian adults (Nutrients . 2020 Apr 26;12(5):1226. https://pubmed.ncbi.nlm.nih.gov/32357534/). Studies have shown that bioactive dietary polyphenol preparations (BDPP) made from grapes resisted memory loss from sleep deprivation (Neurochemistry International. 2015 Oct; 89:191-197. https://www.sciencedirect.com/science/article/abs/pii/S0197018615300255). The mechanisms of improved memory retention and better sleep quality involve the promotion of protein translation in the hippocampus. (FASEB. 2018 Oct; 32(10): 5390-5404https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201800030R).
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